Advanced skin regeneration & repair
Polynucleotides are regenerative injectables designed to improve skin quality at a cellular level. They work by stimulating fibroblasts — the cells responsible for collagen and elastin production — helping to improve skin density, elasticity, hydration, and overall resilience.
They are particularly effective for thin, crepey, damaged, or ageing skin, where traditional fillers or skin boosters are not suitable.
Polynucleotide treatments we offer
Lumi Eyes
(Under-eye treatment only)
Lumi Eyes is a polynucleotide treatment specifically formulated for the delicate under-eye area. It is designed to improve skin quality rather than add volume.
Best for:
- Crepey under-eye skin
- Fine lines under the eyes
- Dark circles caused by thin skin
- Early signs of ageing around the eyes
- Prevention and rejuvenation (commonly 20s–40s)
This treatment helps the under-eye skin appear brighter, smoother, and more resilient, without the heaviness of dermal filler.
Lumi Pro
(Face/skin quality treatment—not for eyes)
Lumi Pro is a higher-strength polynucleotide treatment designed for overall skin regeneration and improved skin quality on the face.
Best for:
- Dull, tired-looking skin
- Poor texture and early laxity
- Fine lines caused by skin thinning
- Dehydrated or stressed skin
- Improving overall skin strength and elasticity
Lumi Pro focuses on repairing and strengthening the skin, making it an excellent option for patients who want healthier-looking skin rather than volume or dramatic change.
Vitaran®
A premium, CE-marked polynucleotide range with higher concentrations:
- Vitaran I – typically used for the under-eye area
- Vitaran II – used for face, neck, and hands
Often selected when a more intensive regenerative approach is needed.
Plinest® (Mastelli)
Often considered a gold-standard polynucleotide, particularly for more mature skin or areas with visible thinning or laxity.
- Plinest Eye – for advanced under-eye rejuvenation
- Plinest Fast – for face and body skin tightening and repair
What results can I expect from Polynucleotides?
- Gradual improvement in skin texture, elasticity, and resilience
- Skin appears healthier, smoother, and more hydrated
- Best results usually seen around 8–12 weeks
Typical course:
- 3–4 sessions, spaced 3–4 weeks apart
- Maintenance depending on skin condition and goals (often 6–12 months)
Profhilo®
Deep hydration & bio-remodelling
Profhilo is a high-concentration hyaluronic acid injectable that improves hydration, firmness, and skin elasticity. It spreads within the skin using a specific technique to remodel tissue rather than add volume.
Best for:
- Dehydrated or dull skin
- Fine lines caused by dryness
- Early skin laxity (especially cheeks and lower face)
- Face, neck, and décolletage rejuvenation
- Patients wanting a quick glow with natural results
Polynucleotides vs Profhilo — what’s the difference?
Polynucleotides (Lumi Eyes, Lumi Pro, Vitaran, Plinest):
- Focus on cellular repair and regeneration
- Ideal for under-eyes, crepey skin, thin or damaged skin
- Results develop gradually and improve skin strength long-term
Profhilo®:
- Focuses on hydration and bio-remodelling
- Ideal for overall glow, smoothing, and hydration
- Results appear faster, often within 1–2 weeks
Can treatments be combined?
Yes—this is very commonly done.
A popular combination includes:
- Lumi Eyes or Plinest Eye for the under-eye area
- Lumi Pro, Vitaran II, or Profhilo for the rest of the face and neck
Your treatment plan will always be personalized following a medical consultation.
Frequently asked questions
Profhilo is a high-concentration hyaluronic acid bio-remodelling injectable that deeply hydrates and improves skin elasticity. Polynucleotides are DNA fragment-based injectables that stimulate fibroblast activity for deeper cellular repair and regeneration.
Profhilo often shows visible hydration and glow within 1–2 weeks, with full effects after the course. Polynucleotides tend to build over several weeks with cumulative improvements.
- Profhilo: usually 2 sessions spaced about 4 weeks apart, then maintenance every ~6 months.
- Polynucleotides: commonly 2–3 sessions spaced 2–4 weeks apart, with possible maintenance every 6-12 months.
Most patients return to normal activities immediately. Temporary redness, small bumps, mild swelling, or bruising at injection sites can occur but usually settle within 24–48 hours.
Results may start to be seen from two weeks after the first appointment.
Typically the best results from HIFU then develop over time as collagen builds up. Many patients will see improvements in skin tightness and texture within 2-3 months.
The effects can last up to a year or more, depending on individual skin condition and the body’s natural ageing process.
Discomfort is generally mild. Fine needles are used, and topical anaesthetic can be offered when appropriate. Most patients find the experience quick and tolerable.
Profhilo is often used on face, neck, and décolletage, and can be used on hands and other areas with skin laxity. Polynucleotides can be used on face, neck, and delicate areas such as under-eyes, where indicated.
Yes — many patients benefit from combining treatments: e.g., Polynucleotides under the eyes for fine lines and delicate skin, and Profhilo on cheeks/face for overall hydration and plumpness.
Results vary by individual, lifestyle, and skin condition. Profhilo typically lasts around 6 months, and polynucleotides can deliver benefits up to 6–12 months with maintenance.
